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This book details recent advances in all aspects related to scale transition in crystal plasticity and damage, with a particular focus on the challenges associated with the characterization and modeling of this class of complex interactions. The following topics are included: - Innovative characterization techniques (multi-scale characterization, SEMTEM coupling, TEM-micro-diffraction coupling, in-situ mechanical tests, localization, image correlation, displacement field measurements, tomography, etc.). - Computational crystal plasticity and damage (dislocation dynamics and ab initio calculations, microstructure evolution of polycrystals, comparison between FE, fast Fourier transform and self-consistent approaches, intragranular slip, heterogeneities, discrete approaches, etc.). The book gathers together selected papers from the invited lectures presented at the 3rd and 4th US-France Symposia organized by the editors under the auspices of the International Center for Applied Computational Mechanics (ICACM).