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Pharmacoresistance in Epilepsy
Anglais
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Although more than 10 new antiepileptic drugs have been developed in the past decade, epilepsy remains resistant to drug therapy in about one-third of patients. The book includes chapters on all issues related to pharmacoresistance in epilepsy and describes recent developments in the pathogenesis and treatment of this disorder. It addresses abnormalities in inhibitory mechanisms, epilepsy-related changes to the immune system, development of pharmacoresistance caused by chronic exposure to antiepileptic drugs, and novel therapeutic strategies for preventing or slowing down the progression of the disease. Several of the studies described in the book use animal models but, because pharmacoresistant epilepsy is currently studied most effectively in humans, the contributors will present several models for translational research that are being used in the field.
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Anglais
