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This volume contains the Proceedings of the Fifteenth American Peptide Symposium (15APS) held in Nashville, Tennessee, on June 14-19, 1997. This biennial meeting was jointly sponsored by the American Peptide Society and Vanderbilt University. The American Peptide Symposium is the most important international peptide meeting, and attracts the largest number of attendees and attention. The attendance of 1081 participants from 37 countries was lower than the two previous Symposia. However, the number of participating countries was the largest. Thus, it was gratifying to see that this meeting retained both its international flavor and participant loyalty at a time when there are many more symposia held each year on similar subjects. §The scientific program comprised 124 oral and 550 poster presentations. The oral presentations together with selected poster presentations are included in this proceedings volume. Together they constitute the most up-to-date advances in peptide science.