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This book covers the applications of multiphase reactors in the energy-related processes, especially to the emerging processes of clean, highly efficient conversion of fossil fuels to chemical products. It provides a comprehensive review on the development and characteristics of conventional and non-conventional multiphase reactors, with topics on the state of the art of applications of multiphase reactors. Each chapter is lead by a process description starting with the basic chemical reaction principles followed by the analysis of reactors for the appropriate reactor selection and concluding with industrial development of multiphase reactors. Many of the topics in the book involve novel reactors, such as downer reactor, dual-riser reactor, plasma reactor, multi-staged fluidized bed, micro-channel reactor, and ultra-supercritical reactor. In particular, case studies will be introduced to illustrate the special features of these reactors.