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This text brings together selected essays of Edwin Mansfield, who has been engaged for almost 40 years in the economics of technical change, a field of importance for analysts and decision-makers. This text presents a quantitative analysis based largely on data collection from firms and other economic units. These essays, which include some of the most frequently cited studies in the field, are concerned with the process of industrial innovation, the nature, composition and effects of industrial research and development, the relationships between technical change, economic growth and inflation, the diffusion of innovations, international technology transfer, public policy toward civilian technology, and intellectual property protection. These topics are central to many current debates among both economic theorists and policy makers.