Impact of M-current on neuronal excitability

The M-current (of the KCNQ2/3 channel) is voltage-§gated potassium current that controls neuronal §excitability. Mutations of the KCNQ2/KCNQ3 genes §cause BFNC, a neonatal form of epilepsy. Despite §substantial research, we do not understand yet the §mechanisms by which M-channels modulate neuronal §excitability. This book, therefore, evaluates the §impact of these channels on the excitability of §hippocampal neurons and transmitter release. It §appraises the impact of M-channels on spontaneous §excitatory/inhibitory post-synaptic currents §(sEPSCs/sIPSCs), as well as miniature EPSCs/IPSCs. §It also assesses the possible contribution of §somatic versus axonal/presynaptic M-channels to §transmitter release, and explores a possible §functional interaction between M-channels and SNARE §proteins such as syntaxin-1A. This book should §provide a basic understanding of the §pathophysiological processes of neuronal §hyperexcitability and also afford a therapeutic §potential for the treatment of major neurological §disorders like epilepsy, migraine or neuropathic §pain. The book is appointed to scientists and to any §person who is interested in this field.