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This volume of the Nebraska Symposium on Motivation will address one of the pressing health concerns in the United States. As asserted in the National Institutes of Health report, Healthy People 2010, health disparities due to race, gender, ethnicity, and social class will become a major threat to the well-being of the nation in this century. The authors have expertise on health disparities across multiple ethnic populations including African Americans, Latinos, Native Americans, and Asian Americans, as well as disparities linked to social class. Health topics to be discussed include violence, academic achievement, substance use, and physical and mental health, among others. The authors will focus on two key issues: (1) major conclusions from theory and research and (2) how their body of work has or could improve human well-being and functioning. The Symposium will prove valuable to students, researchers, educators, service providers, practitioners, and policy makers.