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Handbook for DNA-Encoded Chemistry - Theory and Applications for Exploring Chemical Space and Drug Discovery
Anglais
372 b
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This book comprehensively describes the development and practice of DNA-encoded library synthesis technology. Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening. The book:§Provides a valuable guide for understanding and applying DNA-encoded combinatorial chemistry§Helps chemists generate and screen novel chemical libraries of large size and quality§Bridges interdisciplinary areas of DNA-encoded combinatorial chemistry - synthetic and analytical chemistry, molecular biology, informatics, and biochemistry§Shows medicinal and pharmaceutical chemists how to efficiently broaden available "chemical space" for drug discovery§Provides expert and up-to-date summary of reported literature for DNA-encoded and DNA-directed chemistry technology and methods
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Anglais
