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§This volume of the Series§SpringerBriefs in Space Life Sciences summarizes the newest finding in the field§of mental health and physiological exercise in Space. Currently§two major challenges are impacting human health in the western societies, one§being a move towards a sedentary society, the second one being longevity. Both§have a considerable impact on physical as well as mental health. Space life§science research helps to understand the underlying degenerative physiological§and neuro-psychological processes as living in space, living in microgravity§can be regarded as a time lapse of the sedentary and aging human being.§Translational research of the past years has shown that exercise can be§regarded as a key factor to counteract physical and mental deconditioning in§space, guaranteeing a holistic approach to health and a benefit to the§socio-demographic changes of our society.§§The book is written for scientists in§biomedicine, more specific in aging research, sports physiology and§neurosciences.§§