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This new volume of the "Emerging Infectious Diseases of the 21st Century" series is an up to date, state-of-the-art review on several important infections challenging clinicians, from the general practitioner to the various subspecialists that deals with infections. §Topics were chosen to address new emerging issues and controversies in clinical infectious Disease:§Issues in Central nervous System Infections§Emerging issues in Head & Neck Infections§Current issues in Ventilator-associated pneumonia§Emerging issues in Pulmonary infections of Cystic fibrosis§Re-emergence of childhood respiratory infections in adults §New Concepts & emerging issues in sepsis§Febrile neutropenia: management issues§Emerging issues & trend in Clostriduim difficile colitis§Probiotics in Infections Disease§Device Related Infections§Current concepts of orthopedic implants and prosthetic joint infections§Combination antimicrobial therapies