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This book constitutes the thoroughly refereed post-proceedings of the First International Symposium On Combinatorics, Algorithms, Probabilistic and Experimental Methodologies, ESCAPE 2007, held in Hangzhou, China in April 2007.§The 46 revised full papers presented were carefully reviewed and selected from 362 submissions. The papers address practical large data processing problems with different, and eventually converging, methodologies from major important disciplines such as computer science, combinatorics, and statistics. The symposium provides an interdisciplinary forum for researchers across their discipline boundaries to exchange their approaches, to search for ideas, methodologies, and tool boxes, to find better, faster and more accurate solutions thus fostering innovative ideas as well as to develop research agenda of common interest.