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This book introduces a novel approach to the design§and operation of large ICT systems. It views the technical solutions and their§stakeholders as complex adaptive systems and argues that traditional risk§analyses cannot predict all future incidents with major impacts. To avoid§unacceptable events, it is necessary to establish and operate anti-fragile ICT§systems that limit the impact of all incidents, and which learn from§small-impact incidents how to function increasingly well in changing§environments.§§The book applies four design principles and one§operational principle to achieve anti-fragility for different classes of§incidents. It discusses how systems can achieve high availability, prevent§malware epidemics, and detect anomalies. Analyses of Netflix's media streaming§solution, Norwegian telecom infrastructures, e-government platforms, and§Numenta's anomaly detection software show that cloud computing is essential to§achieving anti-fragility for classes of events with negative impacts.§