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Aneuploidy is one of the most common chromosome abnormalities in human beings. The term 'aneuploidy' refers to any karyotype that does not hold the characteristics of any euploid. Nevertheless, two distinguished traits make the study of aneuploidy very difficult. Firstly, quite frequently it is difficult to identify its causes and consequences. Next, aneuploidy is often connected with a continual deficit in upholding genome stability. Hence, studying aneuploid, unbalanced cells pertains to analyzing a perennially dynamic creature and cataloguing the features that persist. In this book, an overview on the current advancements in comprehending the sources and outcomes of aneuploidy and its link to human pathologies has been presented.