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The contributions to this book, all written by leading experts in their respective disciplines, describe and explore the various facets of regenerative medicine and highlight the role of the "the nano length scale" and of "nano-scale systems" in defining and controlling cell and tissue environments. The development of novel tissue-regeneration strategies requires the integration of new insights emerging from studies of cell-matrix interactions, cellular signalling processes, and developmental and systems biology, into biomaterials design, ideally via a systems approach. The chapters cover a wide spectrum of topics ranging from stem cell biology, developmental biology, cell-matrix interactions, and matrix biology to surface science, materials processing and drug delivery. The book will be an especially valuable resource for researchers developing regenerative medicine paradigms that combine these facets into clinically translatable solutions.