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Urokinase receptor (uPAR) and integrin interactions in Angiogenesis

Language EnglishEnglish
Book Paperback
Book Urokinase receptor (uPAR) and integrin interactions in Angiogenesis Revu Alexander
Libristo code: 06858043
Publishers Sudwestdeutscher Verlag Fur Hochschulschriften AG, May 2012
This thesis aims at elucidating the essential role played by the urokinase receptor (uPAR) in drivin... Full description
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This thesis aims at elucidating the essential role played by the urokinase receptor (uPAR) in driving VEGF induced angiogenesis. On the molecular level the formation of blood vessels from preexisting ones requires the coordinated interaction of the protease system which by their degradation of the extracellular matrix facilitates the adhesion receptors of endothelial cells to invoke migration and invasion. Using flow cytometry and immunohistochemistry based techniques we show that the protease receptor uPAR through its interaction with alpha5beta1 integrins funnels VEGF induced signals for angiogenesis. Inhibition of uPAR interaction with integrins not only impedes endothelial cell migration but also in vivo VEGF induced angiogenesis. In effect uPAR could be investigated as a potential target for angiogenesis based drug therapies.

About the book

Full name Urokinase receptor (uPAR) and integrin interactions in Angiogenesis
Author Revu Alexander
Language English
Binding Book - Paperback
Date of issue 2012
Number of pages 88
EAN 9783838133409
ISBN 3838133404
Libristo code 06858043
Publishers Sudwestdeutscher Verlag Fur Hochschulschriften AG
Weight 141
Dimensions 152 x 229 x 5

Categories

Mathematics & Science > Biology, life sciences
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