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Resistance of Cancer Cells to CTL-Mediated Immunotherapy

Language EnglishEnglish
Book Paperback
Book Resistance of Cancer Cells to CTL-Mediated Immunotherapy Benjamin Bonavida
Libristo code: 15194320
Publishers Springer International Publishing AG, October 2016
This comprehensive volume explores the latest research on the mechanisms of resistance in cancer cel... Full description
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This comprehensive volume explores the latest research on the mechanisms of resistance in cancer cells to CTL-mediated immunotherapy. Chapter topics discuss cell-mediated immunity as the result of cytotoxic T-lymphocytes (CTL) directed specifically against cancer cells. In addition, the volume reviews how CTL mediate the cytotoxic activity, in large part, by the indication of apoptosis; hence, tumor cells develop anti-apoptotic mechanisms and thereby, resist CTL-induced apoptosis. In order for CTL-mediated antitumor immunotherapy to be effective, it is essential that agents directed against the resistant tumor cells sensitized cancer cells for CTL-mediated apoptosis. Examples of such agents discussed in the volume include are HDAC inhibitors, proteasome inhibitors, Bcl-2 family inhibitors, PARP, antibodies, and more.

About the book

Full name Resistance of Cancer Cells to CTL-Mediated Immunotherapy
Author Benjamin Bonavida, Salem Chouaib
Language English
Binding Book - Paperback
Date of issue 2016
Number of pages 353
EAN 9783319380674
ISBN 3319380672
Libristo code 15194320
Publishers Springer International Publishing AG
Weight 6363
Dimensions 155 x 235 x 20

Categories

Medicine & Nursing > Medicine: general issues > Medical equipment & techniques > Medical research
Medicine & Nursing > Clinical & internal medicine > Diseases & disorders > Oncology
Medicine & Nursing > Medical specialties, branches of medicine > Pharmacology
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