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The three plants Leucas cephalotes; Hiptage benghalensis and Kydia calycina has shown an promising protective effect against pain and inflammatory disorders. Different extracts were pharmacological screened against Anti-inflammatory and Analgesic activity. All the extracts showed biological activity in a significant dose dependent manner. These results suggest that the selected plants have anti-inflammatory and analgesic activity by inhibiting the prostaglandins and leukotriens synthesis