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This volume on kallikrein-related peptidases (KLKs) reviews the role of these proteases as biomarkers in a wide range of malignancies including cancers of the lung, prostate, breast, ovary, kidney, stomach, and colon. It provides clinicians, physician scientists, and cancer researchers with in-depth overviews on the emerging clinical relevance of KLK protein or gene expression in these malignancies.