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This volume highlights various aspects of Interleukin 27 (IL-27), especially its possible clinical applications. Topics include the structure, regulation and variability of IL-27, its role in immune regulation and various diseases, such as bacterial, viral and parasitic infections, chronic inflammation in asthma, COPD, psoriasis and inflammatory bowel disease and autoimmune disorders, such as systemic lupus erythematosus, rheumatoid arthritis, Sjogren's syndrome, autoimmune uveitis, multiple sclerosis, autoimmune thrombocytopenia, and cancer.§