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The monograph is devoted to theoretical studies of radiation effects on mammals. It investigates the effects of both acute and chronic irradiation on vital body systems (hematopoiesis, small intestine, and humoral immunity), on the development of autoimmune diseases and on the mortality dynamics in homogeneous and nonhomogeneous (in radiosensitivity) mammalian populations. All are set within the framework of biologically motivated mathematical models. The developed methodology of the studies, the models themselves, and the obtained results are of a great theoretical significance and can find wide practical use for those dealing with the problems of environmental protection and radiation safety.