Aterogennaya modifikaciya lipoproteidov

Initsiiruyushchim momentom aterogeneza yavlyaetsya nakoplenie lipidov v intime arteriy v rezul'tate vzaimodeystviya kletok s assotsiatami modifitsirovannykh LNP. V nastoyashchey rabote provedeno uglublyennoe izuchenie mekhanizmov aterogennoy modifikatsii lipoproteidov nizkoy plotnosti (LNP), tsirkuliruyushchikh v krovi patsientov; issledovany mekhanizmy i rol' assotsiatsii LNP v aterogeneze. Ustanovlena diagnosticheskaya i prognosticheskaya znachimost' LNP-soderzhashchikh tsirkuliruyushchikh immunnykh kompleksov (TsIK), opredelyaemykh po urovnyu kholesterina v nikh (Kh-TsIK), v otnoshenii progressirovaniya rannego ateroskleroza. Pokazano, chto po diagnosticheskoy i prognosticheskoy znachimosti Kh-TsIK znachitel'no prevoskhodit shiroko primenyaemye dlya diagnostiki ateroskleroticheskikh zabolevaniy pokazateli lipidnogo obmena. Vyyavleny amfifil'nye polimery (polaksamery), kotorye v zavisimosti ot ikh gidrofobnykh svoystv vliyayut na samoproizvol'nuyu assotsiatsiyu LNP. Pokazano, chto polaksamery s bol'shey gidrofobnost'yu ostanavlivayut protsess assotsiatsii LNP, no ne vyzyvayut dissotsiatsiyu obrazovavshikhsya kompleksov. Eti veshchestva mozhno rassmatrivat' kak perspektivnye agenty s tochki zreniya pryamoy antiateroskleroticheskoy terapii.