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The purpose of this book is to provide a general guide to statistical methods used in the pharmaceutical industry, and to illustrate how to use S-PLUS to implement these methods. Specifically, the goal is to: Illustrate statistical applications in the pharmaceutical industry; Illustrate how the statistical applications can be carried out using S-PLUS; Illustrate why S-PLUS is a useful software package for carrying out these applications; Discuss the results and implications of a particular application; The target audience for this book is very broad, including: Graduate students in biostatistics; Statisticians who are involved in the industry as research scientists, regulators, academics, and/or consultants who want to know more about how to use S-PLUS and learn about other sub-fields within the indsutry that they may not be familiar with; Statisticians in other fields who want toknow more about statistical applications in the pharmaceutical industry.