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This volume highlights recent advances in the research of neurodegenerative processes and cell death. Also the role of inflammation in neurodegenerative processes is elucidated. A respectable number of articles deals with neuroprotective/neuroregenerative strategies. Although most of this work is preclinical, there is also first evidence from clinical studies that neuroprotection should be possible in neurodegenerative disorders such as Parkinson's disease, amyotropic lateral sclerosis, Huntington's Chorea and eventually also Alzheimer's disease. Top scientists and international opinion leaders discussed and lectured at the 8th International Winter Conference on Neurodegeneration (IWCN) in Tegernsee, Bavaria, Germany, from February 9-13, 2000. And they have put together a valuable, comprehensive and timely piece of work that reviews all the above-mentioned problems and tries to evaluate therapeutic strategies of the future.