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Each volume of "Advances in Pharmacology" provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental. This volume includes reviews on some of the hottest topics in pharmacology, including: multidrug resistance and the MDR1 gene in gene therapy; regulation of calcium channels in epithelial cells; gene therapy and vascular disease; potential therapeutic applications for Heparin; calcium channel blockers; antithrombotic agents; and regulation of potassium channels in epithelial cells.